Mass Gains

Originally conceptualised for treating heart ailments, the studies reported an unusual phenomenon. A large section of the study group, males aged 60 and above, reported to have gotten an erection after years of total clinical impotency.

Further studies showed that the drug was raising the presence of NO or Nitric oxide also referred as Nitrogen mono-oxide. This simple compound can be called as the biggest gift to Male-kind.

After further studies to evaluate the efficacy and safety for long term usage of sildenafil brand named as Viagra for erectile dysfunction, two other prescription products namely Cialis and Levitra saw FDA approvals for this condition

However, even though these products were able to provide men suffering from clinical impotency a much needed sex life back; they also came with a host of other dangerous side-effects and compliance issues

It was during the same period that our research team picked up the information on Nitric oxide and the surprising discovery of it giving impotent men, their erections back

After two years of pain staking research and human clinical trials was born VigaPlus™

VigaPlus™ gave impotent men not only the same or even better quality of erection but also provided them with the only option of permanent and total cure from impotency.

VigaPlus™, THE ONLY IMMEDIATE AND PERMANENT SOLUTION TO IMPOTENCY!

In the ten years that VigaPlus™ has changed the sex lives of millions of men worldwide, the benefits of taking VigaPlus™ is clear:

Benefits:

PROMOTES THE ERECTILE FUNCTION OF THE PENIS WITH FIRMER AND HARDER ERECTIONS
INTENSIFIES YOUR LIBIDO AND APPETITE FOR SEXUAL PLEASURE
STRENGTHENS YOUR SEXUAL STAMINA

How VigaPlus™ works?

VigaPlus™ works on the same principle as VIAGRA, CIALIS and LEVITRA

It works by increasing the Nitric Oxide level in the blood plasma, which causes the smooth muscles to relax leading to vasodilation of the penile arteries and thereby an erection.

Scientific explanation:

NO is produced from the amino acid L-arginine by the enzymatic action of nitric oxide synthase (NOS). There are two endothelial forms of NOS: constitutive NOS (cNOS; type III) and inducible NOS (iNOS; type II). Under normal, basal conditions in blood vessels, NO are continually being produced by cNOS. When NO forms, it has a half-life of only a few seconds, in large part because superoxide anion has a high affinity for NO (both molecules have an unpaired electron making them highly reactive). Therefore, superoxide anion reduces NO bioavailability. NO also avidly binds to the heme moiety of haemoglobin (in red blood cells) and the heme moiety of the enzyme guanylyl cyclase, which is found in vascular smooth muscle cells and most other cells of the body. Therefore, when NO is formed by vascular endothelium, it rapidly diffuses into the blood where it binds to haemoglobin and subsequently broken down. It also diffuses into the vascular smooth muscle cells adjacent to the endothelium where it binds to and activates guanylyl cyclase. This enzyme catalyzes the dephosphorylation of GTP to cGMP, which serves as a second messenger for many important cellular functions, particularly for signalling smooth muscle relaxation.

Cyclic GMP induces smooth muscle relaxation by multiple mechanisms including
1. increased intracellular cGMP, which inhibits calcium entry into the cell, and decreases intracellular calcium concentrations
2. activates K+ channels, which leads to hyperpolarization and relaxation
3. Stimulates a cGMP-dependent protein kinase that activates myosin light chain phosphatase, the enzyme that dephosphorylates myosin light chains, which leads to smooth muscle relaxation.

Because of the central role of cGMP in NO-mediated vasodilation, drugs (e.g., Viagra® , VigaPlus™) that inhibit the breakdown of cGMP (cGMP-dependent phosphodiesterase inhibitors) are used to enhance NO-mediated vasodilation, particularly in penile erectile tissue in the treatment of erectile dysfunction